Tesofensine Weight Loss Treatment

Tesofensine is one of our most popular weight loss treatments for patients of all ages, body weight profiles and genetic makeups.  At Medical Weight Loss Solutions, our expert medical providers offer free consultations regarding Tesofensine administration and other similar programs.  Our Belleville, IL team understands how hard it can be to lose weight and keep it off.  That is why we constantly strive to find and use innovative medications from pharmaceutical brands that have been researched and shown to produce remarkable results for weight loss while improving overall health.  Our due diligence has led us to recently add Tesofensine as one of our most trusted go-to compounds.  

As you will read below, this is another repurposed drug that has been proven safe over years of research but more recently has become a star for the type and quantity of weight loss that it helps impart.  Most patients see results like over 10% body weight, or twenty-five pounds lost in short amounts of time.  The best part, and this what excites our physicians so much, is that this treatment shows an incredibly high proportion of the total weight loss directly coming from the burning of fatty deposits (adipose tissue) and VAT (visceral adipose tissue) as the primary reasons for the decrease in body weight.  This translates to improved overall health as well as promoting the best chances of keeping the weight off long term.  Learn more about getting started with Tesofensine by contacting our medical team today.

tesofensine weight loss pill belleville illinois

What is Tesofensine?

Tesofensine was initially created to help Parkinson’s and Alzheimer’s disease and has been researched since 2001.  Since 2014, it has been discontinued as a neurological treatment due to two factors.  The first is that it did not seem to show a statistically significant difference in treating the symptoms of these two terrible diseases.  The second is due to the fact that some of the trials were stopped due to the side effect of significant weight loss.  This fascinated and sometimes frustrated researchers throughout the many years of studies because this weight loss came in patients who were UNDERGOING NO LIFESTYLE, DIET OR EXERCISE MODIFICATIONS AT ALL!  This was considered a serious side effect because these were not patients looking to lose weight at all.  Thus, what was a loss for one set of diseases has turned into an amazing opportunity for others.  The developers of Tesofensine turned their attention to developing a weight loss medication based on what was seen in the previous studies. Those studies produced tremendous results showing weight loss equal to twice that of any other FDA approved medication at the time and thus lead to the FDA granting conditional or Orphan drug status to Tesofensine to help treat specific weight loss disorders.

Benefits of Tesofensine

  • Promotes Significant Weight Loss
  • Decreased Appetite
  • Increased Basal Metabolic Rate
  • Decreased Abdominal Fat
  • Reduced Cravings
  • Improved Self Esteem
  • Improved Insulin Sensitivity
  • Improved Cognitive Abilities
  • Reduced Feelings of Depression

Side effects can include:

While there are several positive findings in the research of tesofensine treatment, some mild and common side effects for patients include dry mouth, insomnia, tachycardia, constipation, nausea, and high blood pressure. Studies show that the addition of a simple low dose beta blocker mitigates most of these side effects.

How Tesofensine Works

Tesofensine is designed to suppress your appetite and increase the rate of your metabolism by targeting neurotransmitters in the brain. This weight loss suppressant is categorized as a pre-synaptic reuptake inhibitor of serotonin, dopamine, and noradrenaline. When these natural chemicals are potentiated (prevented from being reabsorbed) you will naturally have less cravings, feel less hungry and burn more calories through fat oxidation. This means you’ll no longer need to snack or eat until you’re stuffed for larger meals. As a result, most patients lose over 10% of their body weight while also decreasing hip and waist size.


Tesofensine is taken once daily upon waking and can be administered in three different doses including, 250 mg, 500 mg and 1000 mg capsules. Our providers recommend this medication as a long-term option as studies have shown that weight loss remains consistent even after 6 months. This dosage is recommended once daily and should be taken regularly for at least six months to see permanent and consistent results.

The History of Tesofensine

Tesofensine was developed by a Danish pharmaceutical company as a modern treatment for obesity. However, in its first stages, it was used to treat neurological disorders such as Parkinson’s and Alzheimer’s. The reuptake inhibitor, tesofensine, decrease the loss of serotonin, noradrenaline, and dopamine which controls appetite, energy, and depression, all resulting in weight gain. More recently, tesofensine was approved by the FDA as an anti-obesity medication and has been used successfully since for weight loss reduction.

Frequently Asked Questions

See what our medical providers have to say about some of the most asked questions regarding tesofensine.

At Medical Weight Loss Solutions, we believe in the importance of educating patients on our products. Browse through our most frequently asked questions and get real answers from our medical professionals. Don’t see your question listed? Contact us directly for a one-on-one consultation with someone from our team.

How Does Tesofensine Work?

Tesofensine is a reuptake inhibitor for serotonin, norepinephrine, and dopamine. This means Tesofensine works with the neurotransmitters in the brain to limit food cravings, promote fullness and satiety, reduce overeating or binge eating and stimulate greater metabolic activity resulting in a 6% increase in fat oxidation and resting energy expenditure.

Are There Side Effects While Taking Tesofensine?

There are common and mild side effects that can take place while on tesofensine. Side effects can include dry mouth, insomnia, tachycardia, constipation, nausea, diarrhea, high blood pressure, and increases in heart rate. These effects can be limited by limiting dosing and if needed a mild anti-hypertensive can be added as needed to combat the majority of these symptoms in susceptible individuals.

How Much Weight Will I Lose?

Tesofensine has been the subject of 20 studies over the course of the last 18 years. It has more recently been approved by the FDA for conditional weight loss.  In summary, these studies show a dramatic loss of weight in almost all participants.  In fact, the average weight loss over 6 months was 24.9 lbs. with a significant reduction in visceral fat.

What Is the Right Dosage for Me?

Depending on your current body fat percentage and weight loss goals will determine which dosage is right for your treatment.